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Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing

ACS Nano. 2021 Jan 26;15(1):857-872
Nikhil Pathak, Yun-Ti Chen, Yen-Chao Hsu, Nung-Yu Hsu, Chih-Jung Kuo, Hui Ping Tsai, Jaw-Jou Kang, Chih-Heng Huang, Sui-Yuan Chang, Yu-Hsiu Chang, Po-Huang Liang, and Jinn-Moon Yang*

Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives

Front Pharmacol. 2020 Dec 14;11:606097
Cheng-Wei Yang,† Yue-Zhi Lee,† Hsing-Yu Hsu,† Jia-Tsrong Jan,† Yi-Ling Lin,† Sui-Yuan Chang,† Tzu-Ting Peng, Ruey-Bing Yang, Jian-Jong Liang, Chun-Che Liao, Tai-Ling Chao, Yu-Hau Pang, Han-Chieh Kao, Wen-Zheng Huang, Jiunn-Horng Lin, Chun-Ping Chang, Guang-Hao Niu, Szu-Huei Wu, Huey-Kang Sytwu, Chiung-Tong Chen, and Shiow-Ju Lee*

Enhancement of the IFN-β-induced host signature informs repurposed drugs for COVID-19

Heliyon. 2020 Dec;6(12):e05646
Chen-Tsung Huang, Tai-Ling Chao, Han-Chieh Kao, Yu-Hao Pang, Wen-Hau Lee, Chiao-Hui Hsieh, Sui-Yuan Chang,∗∗∗ Hsuan-Cheng Huang,∗∗ and Hsueh-Fen Juan∗

Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection

EMBO Mol Med. 2021 Jan 11;13(1):e12828.
Kuo-Yen Huang, Ming-Shiu Lin, Ting-Chun Kuo, Ci-Ling Chen, Chung-Chih Lin, Yu-Chi Chou, Tai-Ling Chao, Yu-Hao Pang, Han-Chieh Kao, Rih-Sheng Huang, Steven Lin, Sui-Yuan Chang, Pan-Chyr Yang

Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects

Cell Rep. 2020 Oct 13;33(2):108254
Ya-Wen Cheng, Tai-Ling Chao, Chiao-Ling Li, Mu-Fan Chiu, Han-Chieh Kao, Sheng-Han Wang, Yu-Hao Pang, Chih-Hui Lin, Ya-Min Tsai, Wen-Hau Lee, Mi-Hua Tao, Tung-Ching Ho, Ping-Yi Wu, Li-Ting Jang, Pei-Jer Chen, Sui-Yuan Chang, and Shiou-Hwei Yeh

Experience of the use of hydroxychloroquine on patients with COVID-19: A perspective on viral load and cytokine kinetics

J Formos Med Assoc. 2021 May;120(5):1269-1273
Wang-Da Liu, Sui-Yuan Chang, Ting-Yuan Lan, Yen-Chun Lin, Jui-Hung Kao, Chun-Hua Liao, Ming-Jui Tsai, Po-Hsien Kuo, Yu-Shan Huang, Jann-Tay Wang, Wang-Huei Sheng, Song-Chou Hsieh, Bor-Luen Chiang, Yee-Chun Chen, Shan-Chwen Chang

Endo-Lysosomal Cation Channels and Infectious Diseases

Rev Physiol Biochem Pharmacol. 2020 Aug 4
Yu-Kai Chao, Sui-Yuan Chang, Christian Grimm

The origin and underlying driving forces of the SARS-CoV-2 outbreak

J Biomed Sci. 2020 Jun 7;27(1):73
Shu-Miaw Chaw Jui-Hung Tai, Shi-Lun Chen, Chia-Hung Hsieh, Sui-Yuan Chang, Shiou-Hwei Yeh, Wei-Shiung Yang, Pei-Jer Chen, Hurng-Yi Wang